Clinical trials q1 N*

[Roxanita]

Serious, possibly fatal, adverse effects of a new drug may first appear only after the drug is approved for marketing by the Food and Drug Administration. The failure to detect these effects is best explained by the use of which of the following in the premarketing clinical trials?

A) Healthy rather than ill subjects

B) Lower doses of the drug than are approved for marketing

C) Patients with positive outcomes only

D) Placebos

E) Too few subjects to detect rare events

[Asclepius1]

my answer is E. Rare events requires milion of patients to detect. Just like Vioxx. They have been on the market for many years before it was pulled off the market.

[BlakeH]

Agree with E