q 8

[Anonymous]

The most likely mechanism of a self limited hemolytic intravascular anemia occurring in a 49-year-old man following a treatment with sulfonamide is?

A- piruvate kinase deficiency
B- glucose-6-phosphate dehydrogenase deficiency
C- Mycoplasma pneumoniae infection
D- aplastic anemia iduced by idiosyncrastic adverse reation

[Anonymous]

B- glucose-6-phosphate dehydrogenase deficiency

oxidant drugs such as sulfa drugs (also dapsone in tx of leprosy and primaquine in tx of malaria) is the most common precipitant of hemolytic episodes in G6PD deficiency.

also look for fava beans for mediteranean variant in question stem for clue as precipitant.


ref: kaplan path by goljan sec 2 pg 9-10