Roxanita
10-20-2004, 12:31 PM
Q-1)
A 16-year-old boy is brought to the emergency department because of respiratory distress. Examination shows a large mediastinal mass and 3-cm firm cervical lymph nodes bilaterally. Examination of tissue obtained on cervical lymph node biopsy shows small lymphocytes interspersed with binucleate cells with clear chromatin and large eosinophilic nucleoli. The most likely diagnosis is
A) Burkitt's lymphoma
B) diffuse noncleaved cell lymphoma
C) follicular lymphoma
D) Hodgkin's disease
E) lymphoblastic lymphoma
Q-2)
A 65-year-old man with inguinal adenopathy undergoes a lymph node biopsy. Light microscopy shows replacement of nodal tissue by cells that form well-defined, uniform glandular structures. The nuclei are relatively small and nucleoli are inconspicuous. An immunohistochemical stain for prostate-specific antigen is positive. These findings are most consistent with which of the following?
A) High-grade, high-stage neoplasm
B) High-grade, low-stage neoplasm
C) Low-grade, high-stage neoplasm
D) Low-grade, low-stage neoplasm
Q-3)
A 40-year-old woman has a fever and petechiae. Laboratory studies show:
Hemoglobin 9 g/dL
Leukocyte count 5000/mm3
Neutrophils 10%
Lymphocytes 20%
Blasts 70%
Platelet count 20,000/mm3
A peripheral blood smear shows Auer rods. The most likely diagnosis is
A) acute lymphoid leukemia
B) acute myeloid leukemia
C) chronic lymphocytic leukemia
D) chronic myelogenous leukemia
E) leukemoid reaction
Q-4
A 15-year-old girl has had a sore throat and temperatures to 37.7 C (100 F) for 3 days. Physical examination shows erythematous pharyngeal mucosa and cervical lymphadenopathy. Leukocyte count is 12,000/mm3 with 60% lymphocytes. A slide agglutination test is positive for antibodies against Epstein-Barr virus. This virus is most likely to replicate initially in which of the following cells?
A) Peripheral blood B lymphocytes
B) Peripheral blood monocytes
C) Peripheral blood T lymphocytes
D) Pharyngeal B lymphocytes
E) Pharyngeal monocytes
F) Pharyngeal T lymphocytes
Q-5
A 70-year-old woman has increasing weakness, weight loss, generalized lymph node enlargement, and hepatosplenomegaly. Laboratory studies show absolute lymphocytosis with the majority of cells being CD5+. The patient also has a mild antiglobulin-positive hemolytic anemia. Karyotype is normal. Which of the following is the most likely diagnosis?
A) Acute lymphoblastic leukemia
B) Acute promyelocytic leukemia
C) Chronic lymphocytic leukemia
D) Chronic myeloid leukemia
E) Fanconi's anemia
F) Hairy cell leukemia
G) Myelodysplastic syndrome
H) Myeloid metaplasia with myelofibrosis
I) Polycythemia vera
A 16-year-old boy is brought to the emergency department because of respiratory distress. Examination shows a large mediastinal mass and 3-cm firm cervical lymph nodes bilaterally. Examination of tissue obtained on cervical lymph node biopsy shows small lymphocytes interspersed with binucleate cells with clear chromatin and large eosinophilic nucleoli. The most likely diagnosis is
A) Burkitt's lymphoma
B) diffuse noncleaved cell lymphoma
C) follicular lymphoma
D) Hodgkin's disease
E) lymphoblastic lymphoma
Q-2)
A 65-year-old man with inguinal adenopathy undergoes a lymph node biopsy. Light microscopy shows replacement of nodal tissue by cells that form well-defined, uniform glandular structures. The nuclei are relatively small and nucleoli are inconspicuous. An immunohistochemical stain for prostate-specific antigen is positive. These findings are most consistent with which of the following?
A) High-grade, high-stage neoplasm
B) High-grade, low-stage neoplasm
C) Low-grade, high-stage neoplasm
D) Low-grade, low-stage neoplasm
Q-3)
A 40-year-old woman has a fever and petechiae. Laboratory studies show:
Hemoglobin 9 g/dL
Leukocyte count 5000/mm3
Neutrophils 10%
Lymphocytes 20%
Blasts 70%
Platelet count 20,000/mm3
A peripheral blood smear shows Auer rods. The most likely diagnosis is
A) acute lymphoid leukemia
B) acute myeloid leukemia
C) chronic lymphocytic leukemia
D) chronic myelogenous leukemia
E) leukemoid reaction
Q-4
A 15-year-old girl has had a sore throat and temperatures to 37.7 C (100 F) for 3 days. Physical examination shows erythematous pharyngeal mucosa and cervical lymphadenopathy. Leukocyte count is 12,000/mm3 with 60% lymphocytes. A slide agglutination test is positive for antibodies against Epstein-Barr virus. This virus is most likely to replicate initially in which of the following cells?
A) Peripheral blood B lymphocytes
B) Peripheral blood monocytes
C) Peripheral blood T lymphocytes
D) Pharyngeal B lymphocytes
E) Pharyngeal monocytes
F) Pharyngeal T lymphocytes
Q-5
A 70-year-old woman has increasing weakness, weight loss, generalized lymph node enlargement, and hepatosplenomegaly. Laboratory studies show absolute lymphocytosis with the majority of cells being CD5+. The patient also has a mild antiglobulin-positive hemolytic anemia. Karyotype is normal. Which of the following is the most likely diagnosis?
A) Acute lymphoblastic leukemia
B) Acute promyelocytic leukemia
C) Chronic lymphocytic leukemia
D) Chronic myeloid leukemia
E) Fanconi's anemia
F) Hairy cell leukemia
G) Myelodysplastic syndrome
H) Myeloid metaplasia with myelofibrosis
I) Polycythemia vera