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Roxanita
10-17-2004, 02:31 AM
A 25-year-old man swallows 100 mL of carbon tetrachloride in a suicide attempt. Which of the following is the most likely outcome?

A) Central nervous system failure as a consequence of DNA damage in neurons

B) Gastric toxicity related to erosive gastritis

C) Heart failure as a result of lipid peroxidation of cardiac myocytes

D) No toxicity because the kidneys will excrete the carbon tetrachloride

E) Severe hepatotoxicity as a consequence of damage to the plasma membranes

BlakeH
10-17-2004, 07:56 AM
Answer is E.
CCL4 is metabolized in the hepatocytes SER, producing CCL3, which is a free radical, that causes Lipid peroxidation of intracellular membranes, disaggregation of ribosomes and plasma membrane damage