Candy and Curry mix Question

[asadxyz]

What is the reason Benzodiazepines given parentally in large doses cause respiration depression and death. But if the same dose is given orally does not cause death. V V V STrange.

[RossMIA]

could be due to the first pass effect (hepatic metabolism after absorption from the portal circulation) when given orally

[dua]

coud it be due to different bioavailabilities? PE will have 100% BA so more lethal but only a certain percent of the dose reaches systemic circulation when given orally and plus the first pass effect removes 99% of the drug ( seen only in oral dosage).. reason why lidocaine is given as IV since 99% of it is extracted by the liver and only a fraction would remain in systemic circulation when given orally thus not enough to produce any effect.

[asadxyz]

Both of the explanations concerning 1st pass metaboism and difference in bioavailability are not correct . Pl reconsider and study again you will find the answer. this is a sort homework to both of you OKKKKKKKKKK.

[Anonymous]

Benzodiazepines bind to a subset of the GABA receptor thus decreasing neuronal activity (just as the normal action of GABA) and decreasing brain function; if given parentally in addition to bypassing the first pass effect benz. are rapidly taken up in the brain eventually causing death.

[asadxyz]

I give you a hint about the answer. If you know t he ceiling effect of the benzodiazepines , then you will be able to anwere this question.

[Neuro4u]

Long half life and increased active metabolites.....effects the medulla.