tommyk
04-18-2004, 07:37 PM
Q) What is the rationale for using an ALPHA 1 RECEPTOR BLOCKER for BPH in men? What is one typical drug with this MOA?
A) Alpha receptor blockage causes smooth muscles in the bladder neck and prostate to relax to allow peeing. A significant component of the BPH complex and its associated symptoms is believed to be related to the smooth muscle tension in the prostate stroma, urethra, and bladder neck. The smooth muscle tension in these areas is mediated by the alpha1-adrenergic receptors; therefore, alpha-adrenergic receptor-blocking agents should theoretically decrease resistance along the bladder neck, prostate, and urethra by relaxing the smooth muscle and allowing passage of urine. Phenoxybenzamine or Terazosin are two such agents...
A) Alpha receptor blockage causes smooth muscles in the bladder neck and prostate to relax to allow peeing. A significant component of the BPH complex and its associated symptoms is believed to be related to the smooth muscle tension in the prostate stroma, urethra, and bladder neck. The smooth muscle tension in these areas is mediated by the alpha1-adrenergic receptors; therefore, alpha-adrenergic receptor-blocking agents should theoretically decrease resistance along the bladder neck, prostate, and urethra by relaxing the smooth muscle and allowing passage of urine. Phenoxybenzamine or Terazosin are two such agents...