zero-order kinetics

[crackmle]

Drug showing zero-order kinetics of elimination---
a. are more common that of showing first-oder kinetics
b. decrease in concentration exponentially with time
c. have half life independent of dose
d.show plot concentration verses time that is linear
e.shows a constant fraction of drug eliminated per unit time.

[Dr. X]

a) wrong. first order is common. zero is mostly ethanol, phenytoin(ED), salicylates(TD).
b) wrong. in ZoK - decrease in concentration is constant.
c) wrong. in ZoK - their half life is not fixed and is dependent on dose.
d) Right. plot of concentration vs time should be linear.
e) wrong. in ZoK - it should be constant AMOUNT. if its fraction.. then its FoK.

[crackmle]

yes correct...actually i got confused when i re-read chapter where was mentioned zero-order-->non-linear