Typo in FA? - Quick Ques about antiviral drug

[Unregistered1]

I was just studying my Anti-viral drugs and I think there is a typo in FA 2005. Could someone please help me out and confirm.

On page 294 of the FA 2005, it says that the MOA of Ganciclovir is inhibiting the DNA pol of CMV by phosphorlyation by VIRAL kinase.

It is my understanding that CMV does not have a kinase and therefore acylovir does not work on CMV. I thought Ganciclovir gets phosphorylated by HUMAN kinase (not the viral kinase) and that is why Ganciclovir can work on CMV - but then also has more side effects because it is more toxic to human cells.

So is there a typo in FA? Should it say human kinase rather than viral kinase? Or am I reading or understanding something wrong?

Thanks in advance!

[Dr. X]

key here is we need to know that the either acylclovir or ganciclovir needs to be phosphyralated (activated) in order to work.. but three times!!!

Acylclovir first activated by viral Thymidine kinase and then by host cell (human) kinases to become Acylclovir-triphosphate. Then it goes on to inhibit DNA polymerase by terminating the chain reaction because it does not have ribosyl 3 hydroxyl group.

CMV lacks Thymidine kinase in it (so acylclovir is ineffective)

Ganciclovir becomes Ganciclovir-triphosphate by (all human but virus induced human kinases):
(1) a deoxyguanosine kinase induced by CMV-infected cells
(2) guanylate kinase
(3) phosphoglycerate kinase (source:pub med)

Its not a potent inhibitor of DNA polymerase and it does not terminate the chain reaction (as acylclovir does) and it works against all herpesviridae family. ie HSV, VZV, CMV.

Acylclovir is not hemotoxic but ganciclovir is - neutropenia, thrombocytopenia because ganciclovir works against rapidly replicating cells such as neutrophil and platelet. They both cause crystalluria (so maintain hydration) and could be neurtotoxic (seizure).

and good to know that they're both guanine analogues. maybe a mol bio. aspect of it. if its foscarnet (inhibitor of DNA polyermase AND reverse transciptase - broader antiviral) and it is an pyrophospate analogue.

If CMV retinitis - go for foscarnet. (usually in aids pxt) cause its a Rev. Transcriptase too.. as for FA.. it happens every edition.