VDJ stuff

[IMG SURVIVOR]

Who can tell me about that stuff of VDJ:confused:
and why do we need to know this?

[stateofequilibrium]

No idea, but it was on my test with a diagram and I did "ee-nee-manee-moe, catch a tiger his toe"

[IMG SURVIVOR]

No idea, but it was on my test with a diagram and I did "ee-nee-manee-moe, catch a tiger his toe"

:crackingup: Thats exactlly what I do with questions I have never heard before.



I just found out this

V ariable
D iversity
J oining

With B lynphocyte:confused:

Who else ca help

[Sree Cheruku]

vdj system is the means by which b cells are able to produce variety in the variable regions of the antibodies they produce

the genes for Ig light chains have V and J segments - which undergo recombination; similarly, the genes for Ig heavy chains have V, J and D segments

the enzyme responsible for recombination between v, j and d is called tdt. its found in pro-B and pre-B cells. after v, d, and j are rearranged, the next genetic element downstream from them is the mu gene which codes for IgM - which is why IgM is the native configuration of antibodies before class switching occurs.

after recombination, if the product is functional, the rearrangement process is turned off. the antibody molecule is now able to recognize antigens which match their vdj configuration.

here's a pic from images.google:

http://www.biology.arizona.edu/immunology/tutorials/immunology/graphics/recombination98.gif

its been 3 months since ive looked at this stuff, so feel free to correct any mistakes - lange micro+immuno and the kaplan immuno notes are a good reference for this stuff. each devotes a chapter to the topic

[stateofequilibrium]

:crackingup: Thats exactlly what I do with questions I have never heard before.



I just found out this

V ariable
D iversity
J oining

With B lynphocyte:confused:

Who else ca help

I knew what it was. But they were asking the mechanism by which it works in relation to particular diagram. I sat there blubbering and crying for a minute.

[MDiva]

the enzyme responsible for recombination between v, j and d is called tdt. its found in pro-B and pre-B cells. after v, d, and j are rearranged, the next genetic element downstream from them is the mu gene which codes for IgM - which is why IgM is the native configuration of antibodies before class switching occurs.

THANK YOU!!!!!!!

[IMG SURVIVOR]

Thanks for the nice explanation with picture.