Diuretic Q

[GFLIP]

Which of the following diuretic has the unique side effect of Ototoxicity?

A. Loop diuretics
B. Thiazide diuretics
C. Potassium sparing diuretics
D. Osmotic diuretics

[preetin]

the answer is A

[GFLIP]

what should you be concerned about when you have a loop diuretic and a cardiac glycoside?

[mammypriya]

hypokalemia and hypomagnesemia.causes pvc.

[GFLIP]

what's the MOA?

[mammypriya]

piss it out with the diuretic.with dig you block the ions(lowering it) it so it can do its job.:evil: stop gflip u r making me think.
jk:D i hope i am right!!!

[GFLIP]

sorry for making you think... shame on me. ;) ;) ;)

The diuretic causes hypokalemia... this is bad if your taking digoxin b/c digoxin and K+ compete for the same site on the Na+/K+ ATPase... you'll get digoxin toxicity...

[mammypriya]

for some reason i had a completely different understanding of this concept...not the diuretic part .dig blocking part...if you have a few minutes please explain it.if you have low pottasium how do u compete???or did i miss the boat completely ?sorry for making you think... shame on me. ;) ;) ;)

The diuretic causes hypokalemia... this is bad if your taking digoxin b/c digoxin and K+ compete for the same site on the Na+/K+ ATPase... you'll get digoxin toxicity...

[MDiva]

If digoxin and K+ compete for the same ATPase, then in case of hypokalemia, K+ is actively using its ATPase to get excreted. Digoxin therefore cannot use it, and stays in the system...I think. Someone help me out if I am thinking about this the wrong way.

[GFLIP]

If you have hypokalemia, there will be increased Digoxin binding to Na+/K+ ATPase (b/c there's less K+ competing with Digoxin). This will enhance Digoxin toxicity.

...helps?

[MDiva]

If you have hypokalemia, there will be increased Digoxin binding to Na+/K+ ATPase (b/c there's less K+ competing with Digoxin). This will enhance Digoxin toxicity.

...helps?

I must be driving on the wrong side of the road :rolleyes:

Thanks, GFLIP! :cool:

[NCmed]

I just realized it and wanted to share...MOA of acetazolamide in altitude sickness:create a metabolic acidosis ,so compensate the respiratory alkalosis (hyperventilation) of high altitude.

[NCmed]

that's right:D , if K+ and digoxin both compete for Na+/K+ATPase ,in hypokalemic situation, K+ is out of competition since he's low,then digoxin has free access and win the race, the same way,hyperkalemia reduces the effects of digoxin.

My Question:what is the MOA of using thiazides in nephrogenic diabetes insipidus?:confused:

[IMG SURVIVOR]

If the patient is allergic to furosemida what other loop medication would you prescribe?

[mammypriya]

sulfa allery-->>ethacrinic acid