NM blocking Q

[GFLIP]

:confused: Which neuromuscular blocking agent can cause the greatest release of histamine?

a. Pancuronium
b. Succinylcholine
c. Mivacurium
d. Rocuronium
e. Sildenafil
f. Tubocurarine

[rd100]

succinlycholine....paralizes/pruritis ...if only you could move to itch...thats how i remember it good luck

RD
SGUSOM

[pharmy]

:confused: Which neuromuscular blocking agent can cause the greatest release of histamine?

a. Pancuronium
b. Succinylcholine
c. Mivacurium
d. Rocuronium
e. Sildenafil
f. Tubocurarine

F. Tubocurarine

[GFLIP]

nice pharmy... that's correct.

[mammypriya]

AGREE WITH pharmy...tubocurarine.high amt of histamine realeased-->decreases blood pressure.also bronchospasm causer.

[MDiva]

What's the MOA for this increase of histamine by tubocurarine? Contrast with succinylcholine.

[GFLIP]

need help... i can't answer this...

all i know is that muscle relaxants can cause dose-dependent histamine release

[niharhotchandani]

histamine release by d- tc is not immunologic, histamine has a positive charge and is stored with negatively charged heparin and a protein in the mast cells...... the release of histamine is mainly related to the BULKY CATIONIC structure of d-tc .....in contrast succinyl choline and the newer competitive blockers have slender flexible molecules , thereby no histamine release!!!!!!!!

[GFLIP]

wow......nice info niharhotchandani.