regarding FLUTAMIDE

[azaheer]

Hello, to every one :p

my question is:

how does FLUTAMIDE treat prostatic cancer though it increases LH and testosterone level ?? :confused:

and

how does it cause gynecomastia if the androgen level is the one which increase ?? :confused:

i wish you could help in these ..

[Hatim]

i belive u have to give it with another drug goserlin to prevent the inital flare up from flutamide and then negative feed back kicks in.
hope i'm rite any one else?

[SONALI SEN]

Flutamide Is A Non Steroidal Compound And Essentially An "androgen Receptor Inhibitor"......so It Does Not Allow Androgen To Have Its Effect On Prostate.....and Therefore Helpful In The Treatment Of Prostate Cancer......
And Since The Male Hormone Does Not Act On The Androgen Receptors Elsewhere In The Body....the Patient Tends To Have Gynaecomastia.....

[azaheer]

Flutamide Is A Non Steroidal Compound And Essentially An "androgen Receptor Inhibitor"......so It Does Not Allow Androgen To Have Its Effect On Prostate.....and Therefore Helpful In The Treatment Of Prostate Cancer......

thanx for the explanation :idea:

And Since The Male Hormone Does Not Act On The Androgen Receptors Elsewhere In The Body....the Patient Tends To Have Gynaecomastia.....

still not convinced :confused:

[GFLIP]

Aromatase converts the testosterone into estradiol. Excess estradiol leads to proliferation of breast tissue.

[SONALI SEN]

thanks GFLIP....for the explanation.

[GFLIP]

... glad to help ...

[azaheer]

Aromatase converts the testosterone into estradiol. Excess estradiol leads to proliferation of breast tissue.

I dont wanna be a pain :( but :

from where aromatase came from???
:confused: :confused: :confused:
thanx in advance

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[SONALI SEN]

aromatase is an enzyme of cytP450 group whose function is to convert androstenidione to estrone...... and testosterone to estradiol.

In humans gene cyp19 located on chr no 15q21 encodes for this enzyme.

The enzyme aromatase is found in many organs including gonads ,brain,adipose tissue,placenta,blood vessels,skin,bone,endometrium.
http://upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Reaction-Testosterone-Estradiol.png/250px-Reaction-Testosterone-Estradiol.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png)
Aromatase converts testosterone to estradiol

http://upload.wikimedia.org/wikipedia/commons/thumb/b/b9/Reaction-Androstendione-Estrone.png/250px-Reaction-Androstendione-Estrone.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png)
Aromatase converts androstenedione to estrone

[SONALI SEN]

aromatase is an enzyme of cytP450 group whose function is to convert androstenidione to estrone...... and testosterone to estradiol.

In humans gene cyp19 located on chr no 15q21 encodes for this enzyme.

The enzyme aromatase is found in many organs including gonads ,brain,adipose tissue,placenta,blood vessels,skin,bone,endometrium.
http://upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Reaction-Testosterone-Estradiol.png/250px-Reaction-Testosterone-Estradiol.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png)
Aromatase converts testosterone to estradiol

http://upload.wikimedia.org/wikipedia/commons/thumb/b/b9/Reaction-Androstendione-Estrone.png/250px-Reaction-Androstendione-Estrone.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png)
Aromatase converts androstenedione to estrone

[azaheer]

aromatase is an enzyme of cytP450 group whose function is to convert androstenidione to estrone...... and testosterone to estradiol.

In humans gene cyp19 located on chr no 15q21 encodes for this enzyme.

The enzyme aromatase is found in many organs including gonads ,brain,adipose tissue,placenta,blood vessels,skin,bone,endometrium.
http://upload.wikimedia.org/wikipedia/commons/thumb/a/ad/Reaction-Testosterone-Estradiol.png/250px-Reaction-Testosterone-Estradiol.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Testosterone-Estradiol.png)
Aromatase converts testosterone (http://en.wikipedia.org/wiki/Testosterone) to estradiol (http://en.wikipedia.org/wiki/Estradiol)

http://upload.wikimedia.org/wikipedia/commons/thumb/b/b9/Reaction-Androstendione-Estrone.png/250px-Reaction-Androstendione-Estrone.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png) http://en.wikipedia.org/skins-1.5/common/images/magnify-clip.png (http://en.wikipedia.org/wiki/Image:Reaction-Androstendione-Estrone.png)
Aromatase converts androstenedione (http://en.wikipedia.org/wiki/Androstenedione) to estrone (http://en.wikipedia.org/wiki/Estrone)

simple, easy and with diagrams
i couldnt ask for more:D

god bless u
;)

[SONALI SEN]

Thanks .....in Fact....i Myself Learnt A Lot From This Forum.....and From This Post.