physio / pharm Q

[GFLIP]

A 56 year old male bipolar patient is treated with lithium. He starts to notice polyuria. Which drug would reduce urine flow due to lithium in this patient?

a. adenosine
b. ACE inhibitors
c. dopamine
d. vasopressin
e. thiazide diuretics

[superoxide]

A 56 year old male bipolar patient is treated with lithium. He starts to notice polyuria. Which drug would reduce urine flow due to lithium in this patient?

a. adenosine
b. ACE inhibitors
c. dopamine
d. vasopressin
e. thiazide diuretics

I think its vasopressin

[GFLIP]

the answer is e.

[superoxide]

the answer is e.

why would you use a diuretic in someone who already has polyuria??

[GFLIP]

Thiazides cause an initial reduction of sodium reabsorption in the distal tubule increases sodium excretion and causes extracellular fluid volume contraction. As a result, the glomerular filtration rate decreases and the proximal tubular sodium and water reabsorption increases. Consequently, less water and sodium are delivered to the collecting tubules and, as a result, less water is excreted.

Tricky, right?!?!

[sarab]

why not the vasopressin. with ADH we can treat this pt

[Anisha2939]

it wouldnt b lithium because, lithium doesnt alter or decrease ADH secretion, instead it decreases the permeability of the collecting ducts which results in nephrogenic DI.......u can not treat nephrogenic DI with vasopressin/ADH b/c its the receptor problem

[ORD]

answer is E Guys, GFLIP already broke it down nicely...

[IMG SURVIVOR]

Also remember that Lithium can also gives you Hypothyroidism.