hiran
11-04-2006, 09:59 AM
hi,took nbme 1 and found these questions for which i want answers and explanations
1.a 50yr old man had MI,dignosed as familial hypercholesterolemia(AD).Son not tested yet,what is the probability of this man's granddaughter to get this disease thro son
a)less than1% b)25%c)50%d)10%e)33%
2.normal children are able to mount responses to variable no of antigens.this is possible by which of the following DNA mechanism
a)amplification b)recombination c)conformation d) repair e)replication
3)
ΔG0′
V ↔ W – 4.0
W ↔ X +0.4
X ↔ Y – 3.4
Y ↔ Z + 5.7
From the values of ΔG0′ given in the table, which compound in the overall metabolic pathway V ↔ W ↔ X ↔ Y ↔ Z will accumulate in the largest amount at equilibrium?
A) V
B) W
C) X
D) Y
E) Z
4)(Cleft lip picture)…..The developmental anomaly shown in this stillborn fetus is most commonly characterized by which type of inheritance?
A) Autosomal dominant
B) Autosomal recessive
C) Mitochondrial
D) Multifactorial
E) Sex-linked
5)
A female neonate has profound hypotonia. The only known complication of pregnancy was polyhydramnios. The mother has a lack of facial expression and weak muscles; she says she did not have any problems as an infant or child. Which of the following best explains the difference in presentations in the mother and child?
A) Anticipation
B) Delayed onset
C) Genetic heterogeneity
D) Incomplete penetrance
E) Pleiotropy
6) sorry I am not able to post the pedigree chart.hope you remember.In the family represented by the pedigree, affected persons have a disease characterized by mitochondrially inherited late-onset optic atrophy. Assuming that the family and personal medical history of the partner is unremarkable, the risk for optic atrophy to develop in the male child of IV-9 is closest to
A) 0%
B ) 25%
C ) 50%
D ) 75%
E ) 100%
1.a 50yr old man had MI,dignosed as familial hypercholesterolemia(AD).Son not tested yet,what is the probability of this man's granddaughter to get this disease thro son
a)less than1% b)25%c)50%d)10%e)33%
2.normal children are able to mount responses to variable no of antigens.this is possible by which of the following DNA mechanism
a)amplification b)recombination c)conformation d) repair e)replication
3)
ΔG0′
V ↔ W – 4.0
W ↔ X +0.4
X ↔ Y – 3.4
Y ↔ Z + 5.7
From the values of ΔG0′ given in the table, which compound in the overall metabolic pathway V ↔ W ↔ X ↔ Y ↔ Z will accumulate in the largest amount at equilibrium?
A) V
B) W
C) X
D) Y
E) Z
4)(Cleft lip picture)…..The developmental anomaly shown in this stillborn fetus is most commonly characterized by which type of inheritance?
A) Autosomal dominant
B) Autosomal recessive
C) Mitochondrial
D) Multifactorial
E) Sex-linked
5)
A female neonate has profound hypotonia. The only known complication of pregnancy was polyhydramnios. The mother has a lack of facial expression and weak muscles; she says she did not have any problems as an infant or child. Which of the following best explains the difference in presentations in the mother and child?
A) Anticipation
B) Delayed onset
C) Genetic heterogeneity
D) Incomplete penetrance
E) Pleiotropy
6) sorry I am not able to post the pedigree chart.hope you remember.In the family represented by the pedigree, affected persons have a disease characterized by mitochondrially inherited late-onset optic atrophy. Assuming that the family and personal medical history of the partner is unremarkable, the risk for optic atrophy to develop in the male child of IV-9 is closest to
A) 0%
B ) 25%
C ) 50%
D ) 75%
E ) 100%