Question for Retinoic Acid

[YuQX]

Several clinical trials have suggested that retinoic acid can induce remission in patients with acute promyelocytic leukemia. Such remission is related to the ability of retinoic acid to promote which of the following?

A) Differentiation of leukemic cells

B) Differentiation of monocytes into macrophages

C) Generation of cytotoxic T lymphocytes

D) Production of interferon

E) Repair of DNA damage

[md90]

Several clinical trials have suggested that retinoic acid can induce remission in patients with acute promyelocytic leukemia. Such remission is related to the ability of retinoic acid to promote which of the following?
A) Differentiation of leukemic cells
B) Differentiation of monocytes into macrophages
C) Generation of cytotoxic T lymphocytes
D) Production of interferon
E) Repair of DNA damage

If you have the Goljan's Rapid Review Pathology... it's page 150, and he talks about it in his lectures. Acute Promyelocytic Leukemia is associated with an abnormality in retinoic acid metabolism therefore high doses of Vitamin A may induce remission by maturing the cells.

[YuQX]

Thank you, md90!
I checked the book, so the answer is A.

[md90]

yes... I thought that I had bolded the answer.. but must have forgotten... sorry about that.. will change that right now..

[stranger2]

that was a qtion in NMBE one

[YuQX]

I didn't realize you bolded A. Thank you again!