md90
04-27-2006, 01:28 AM
What other anti-metabolites are used in the S-phase in cancer chemotherapy?
metoaptopurine and thioguanine--purine analogues that inhibit purine synthesis; azaacytidine--limits pyramidine synthesis by inhibiting orotidylate decarboxylase; hydroxyurea--inhibits formation of deoxyribonucleotides from ribonucleotides; 5-Fluorouracil--inhibits thymidylate synthase; cytarabine (AKA cytosine arabinoside)--inhibit DNA polymerase
metoaptopurine and thioguanine--purine analogues that inhibit purine synthesis; azaacytidine--limits pyramidine synthesis by inhibiting orotidylate decarboxylase; hydroxyurea--inhibits formation of deoxyribonucleotides from ribonucleotides; 5-Fluorouracil--inhibits thymidylate synthase; cytarabine (AKA cytosine arabinoside)--inhibit DNA polymerase