md90
04-27-2006, 01:02 AM
A very ill infant admitted to the hospital; lab exam: very high serum concentration of lactic acid. In addition to taking steps to correct the acidosis, the attending physician prescribes thiamine. The rationale for thiamine administration is that the thiamine is converted to a coenzyme used by which enzyme?
Pyruvate dehydrogenase
--can you name other information r/t thiamine?
1. water soluble vitamin
2. converted to coenzyme thiamine pyrophosphate
3. used to convert pyruvate to acetyl-CoA
4. in its' absence, is converted to lactate dehydrogenase then to lactate which flows in the blood leading to lactic acidosis
Pyruvate dehydrogenase
--can you name other information r/t thiamine?
1. water soluble vitamin
2. converted to coenzyme thiamine pyrophosphate
3. used to convert pyruvate to acetyl-CoA
4. in its' absence, is converted to lactate dehydrogenase then to lactate which flows in the blood leading to lactic acidosis