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05-31-2008, 05:05 PM
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CD3,4,5,8,19,20,23,10,TdT,B7,80,86,40,41,38,138,79 a,Throw in PAX5 and TRAP as well. That's off of top of my head I would consider most important.
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IM[x] Surgery [  ]Life is like a box of chocolates, keep your nose away from my box 
    
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05-31-2008, 05:30 PM
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ugh........
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AUC Post-Step 1 Undergrad: UC Riverside
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05-31-2008, 05:32 PM
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Quote:
and their cell type too?
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05-31-2008, 05:44 PM
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thats what google is for =)
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AUC Post-Step 1 Undergrad: UC Riverside
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05-31-2008, 07:26 PM
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Well, 3,4,8 are basic T cell markers. CD56 and 16 are for NK cells. CD5 important in differentiating CLL as it is a T cell marker present on B cell. CD 19,20,23 are B cell markers often used in flow cytometry. TdT is a marker of precursor B or T cell leukemia. CD10 is a marker of immature B cell. B7akaCD80 binds CD28 and is important in priming T cell and consequentially in tumor therapies. CD80 (B7)/86 T cell activation. CD40 of APCs binds CD40L of T cell activating them. CD41 is IIb/IIIa complex. CD38 and 138 in multiple myeloma plus 38+ and ZAP70+ B cells have grim prognosis for CLL while negative give about 25year survival. 79a is marker of lymphoplasmacytic lymphoma which is a common cause of waldenstrom's hyperIgM. PAX5 and TRAP are markers of hairy cell leukemia.
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IM[x] Surgery [ ]Life is like a box of chocolates, keep your nose away from my box
Last edited by BiologyBY; 05-31-2008 at 07:29 PM.
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05-31-2008, 07:28 PM
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05-31-2008, 07:37 PM
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CD1 action is yet to be determined by it is found on APCs and serve as lipid antigen presentors to T cells. Also, CD21 binds C3d in complement system and B cells have receptors for it. This same receptor for CD21 is the one EBV binds to. By the way I've edited something on CD80/86 there, not B but T cell activation. Also, CD23 I forgot to mention is a low affinity IgE receptor on B cell (Fc epsilon RII).
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IM[x] Surgery [ ]Life is like a box of chocolates, keep your nose away from my box
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