Quote:
Originally Posted by darkmansaad
Just wondering exactly the disparity between the two. Cuz i am getting murdered on UsmleWorld biochem like 60% i think and am wondering if i have to know obscure details about TCA cycle...for example I had no idea that methylmalonyl CoA was isomerized in a B12 dependent reaction to Succinyl CoA ....or maybe im an idiot i dont know. Possibly both.
input?
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hey,
the reason thats important is more to do with B12 deficiency , its in FA biochem vitamin section pg 80 (2007 edition), its pretty highyield...the thing i find about UW, they test these HY facts but in the most absurd way,
but succinyl CoA can enter the heme synthesis pathway or TCA cycle
and the build up of methylmalonyl CoA and proplonyl CoA are supposed to cause demylination, which is why u have neurologic sx's with B12 def Vs. B6
but i totaly agree with you on UW sometimes when im going through q's i have this rxn ->
(A)propionyl CoA carboyxylase (biotin cofactor)
(B)methylmanlonyl mutase(b12)
propionyl-CoA---------------->methylmalonyl CoA------>succinyl CoA
(so i cant figure out how to put the enzymes over the arrows, but
(A) is the enzyme responsible for propionyl-CoA to methylmalonyl CoA
(B) is responsible for methylmalonyl CoA to succinyl CoA)
hope that makes sense , golijan does a good job too in his vitamin section